Shifting energy metabolism

Energy metabolism and obesity.

Over the long-term, most adult humans are able to maintain body energy stores through the process of energy balance, which regulates how much energy is consumed to match how much energy is expended. Energy expenditure is required for resting metabolic rate to maintain basic physiologic functions (e.g., heart beat, muscle function, respiration) and metabolize, digest, and store food that is cons...

Energy in Ancient Metabolism

Modern metabolism would not work without ATP and phosphate, but in primordial biochemical networks, energy currencies might have been simpler. Goldford et al. report a novel systems approach to reconstructing energetics in ancient metabolism, with very interesting results.

SIRT1 and energy metabolism.

Sirtuin 1 (SIRT1) is the most conserved mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. In response to different environmental stimuli, SIRT1 directly links the cellular metabolic status to the chromatin structure and the regulation of gene expression, thereby modulating a variety of cellular processes such as energy metabo...

Energy metabolism after injury.

Myocardial Energy Metabolism

The effects of fructose 1,6-bisphosphate (F-1,6-P2) on the isolated Langendorif-perfused heart were studied by monitoring flavoprotein fluorescence, oxygen consumption (MV02), coronary flow (FJ, systolic intraventricular pressure (PYS), diastolic intraventricular pressure, and contraction frequency. The cellular energy state and cytosolic pH were determined by means of 31p nuclear magnetic reso...